Cross-cut: `ingestible`

Axis: form_factor

5 corpus entries disclose this tag.

Earliest disclosure: 1966-08-24

Listed in chronological order. Each entry’s prior_art_notes and disclosure_citation constitute the citeable prior art material.

Fantastic Voyage — miniaturized intravascular craft navigating the body (1966-08-24)

id: fantastic-voyage-intravascular-craft
corpus: fictional
form factor: ingestible
creator: Richard Fleischer / 20th Century Fox; novelization Isaac Asimov
disclosure: Fantastic Voyage (20th Century Fox), released August 24, 1966 (Isaac Asimov novelization, 1966); a miniaturized crewed craft is introduced into a patient’s bloodstream and navigates the vasculature to reach and treat an internal target, in two-way communication with an external control station.
ip status: fictional
prior art notes: Discloses a small device introduced into the bloodstream that locomotes through the vasculature under guidance, reaches an internal target, performs an intervention there, and maintains a telemetry link to an external operator station. Relevant to intravascular microrobot / in-body capsule claims combining ‘a device sized to traverse a blood vessel’, ‘a propulsion or navigation means’, ‘a therapeutic or sensing payload’, and ‘a wireless link to an external controller’ — the modern microrobotics / capsule-endoscopy / intravascular-robotics patent space. § 103 motivation that the navigable in-bloodstream device was an articulated objective by 1966. Non-enabling on miniaturization.

id: the-matrix-navel-tracking-bug
corpus: fictional
form factor: ingestible
creator: The Wachowskis / Village Roadshow
disclosure: The Matrix (Warner Bros. / Village Roadshow), released March 31, 1999; a small robotic device is introduced into a person through the navel, burrows into and lodges in the abdomen, and serves as a covert tracking/surveillance implant until later located and extracted.
ip status: fictional
prior art notes: Discloses a small device introduced into the body through a natural opening that actively migrates to and anchors at an internal site and then functions as a covert tracking/sensing implant, locatable and retrievable afterward. Relevant to ingestible/implantable migrating-capsule claims combining ‘a device introduced via a body orifice’, ‘self-locomotion to an internal site’, ‘an anchoring mechanism’, and ‘a tracking or sensing function’ — adjacent to capsule-endoscopy, ingestible-sensor, and locatable-implant patents. § 103 motivation that the migrating, self-anchoring in-body capsule was an articulated objective by 1999.

id: iddan-2000-wireless-capsule-endoscopy
corpus: academic
form factor: ingestible
creator: Gavriel Iddan / Gavriel Meron / Arkady Glukhovsky / Paul Swain (Given Imaging)
disclosure: Iddan G, Meron G, Glukhovsky A, Swain P. ‘Wireless capsule endoscopy.’ Nature 2000;405(6785):417.
ip status: public-domain
sensors: sensor-camera-rgb
prior art notes: Discloses a swallowable wireless capsule incorporating an imaging sensor, illumination, transmitter and battery that captures and transmits images of the gastrointestinal mucosa as it passes through the gut — i.e. the ingestible camera. Any claim reciting ‘an ingestible capsule comprising an image sensor and a wireless transmitter for imaging the gastrointestinal tract’ reads on Iddan et al. 2000. Anchor for the ingestible × camera cross-cut; product realization in [[pillcam-given-imaging-2001]]; cf. the fictional antecedents [[fantastic-voyage-intravascular-craft]] (1966) and [[the-matrix-navel-tracking-bug]] (1999).

id: pillcam-given-imaging-2001
corpus: private
form factor: ingestible
creator: Given Imaging Ltd. (founders Gavriel Iddan, Gavriel Meron)
disclosure: Given Imaging Ltd. (later Medtronic). ‘M2A’ capsule (subsequently ‘PillCam SB’) wireless capsule endoscope, FDA-cleared 1 August 2001 — a swallowable capsule with a CMOS image sensor, LED illumination, battery and radio that images the small-bowel mucosa over ~8 hours, transmitting frames to an external belt-worn receiver/recorder. CE-marked May 2001; renamed PillCam SB in September 2004.
ip status: patented
sensors: sensor-camera-rgb
prior art notes: Discloses the commercial ingestible imaging capsule: a swallowable CMOS-camera capsule with onboard illumination, battery and radio, imaging the GI mucosa during transit and streaming frames to a body-worn receiver/recorder. Product realization of [[iddan-2000-wireless-capsule-endoscopy]]; anticipates ingestible-camera claims from 2001. Anchor for the ingestible × camera cross-cut on the real side.

id: proteus-abilify-mycite-2017
corpus: private
form factor: ingestible
creator: Otsuka Pharmaceutical Co. / Proteus Digital Health, Inc.
disclosure: Otsuka Pharmaceutical Co., Ltd. and Proteus Digital Health, Inc. ‘Abilify MyCite’ (aripiprazole with embedded ingestible event marker), FDA-approved 13 November 2017 — the first drug-device combination approved by the FDA with an integrated ingestible sensor: a millimeter-scale sensor embedded in each tablet that activates on contact with stomach fluid and transmits to a skin-worn patch (‘MyCite Patch’), which relays an ingestion event to a smartphone, confirming medication adherence.
ip status: patented
sensors: sensor-bioimpedance
prior art notes: Discloses a drug-device combination in which each medication tablet incorporates a tiny edible sensor that activates on contact with stomach fluid (powered by the electrochemical reaction with stomach acid), communicating an ingestion event to a skin-mounted receiver patch that relays it to a smartphone. The first FDA-approved digital-pill / medication-adherence-tracking system. Anticipates ingestible-sensor medication-adherence claims combining ‘an ingestible sensor embedded in or co-delivered with a pharmaceutical’, ‘a skin-worn receiver/patch’, and ‘transmission of an ingestion-event record’ from 2017. Anchor for the ingestible × adherence cross-cut.